hebetor. However, the hemolymph of P. interpunctella injected into Galanthus nivalis L. agglutinin (the positive control) had significant negative impact on these biological parameters of H. hebetor. The results indicate that H. hebetor are not sensitive to Cry1C protein at the tested concentration and there were no detrimental effects of Cry1C protein on any biological parameters tested in the present study. More importantly, we constructed a new efficient and simple system for the biosafety assessment on the larvae of ectoparasitoid of target pest.A vital approach for sustainable development is to achieve continuous synergies of ecosystem services (ESs). The implementation of Grain for Green Program (GFGP) in China has altered land use pattern and further affected ESs. The Loess Plateau, one of the crucial areas of GFGP, has a barren ecosystem. Thus, it is urgent to analyze trade-offs and synergies of ESs as it seeks to make rational use of natural resources. In this paper, three ESs (food supply (FS), water yield (WY), and habitat quality (HQ)) were selected to illustrate their relationships and changes during the implementation of GFGP. Accordingly, the correlation coefficient, the spatial autocorrelation, and the hotspot method were adopted to analyze the spatial agglomeration effect at the grid scale and the village scale. The obtained results indicated that the spatial distribution of the three ESs had their own characteristics. There is a synergy of WY and FS, and trade-offs of WY and HQ, and HQ and FS, respectively. Notably, the trade-offs and synergies of ESs were consistent at two scales, though the correlation coefficient was slightly different. Compared with the grid scale, the agglomeration effect on the village scale is more obvious. To promote region sustainable management, the interrelation of ESs should be taken into account in the eco-conservation policies.Alemtuzumab is a monoclonal anti-CD52 antibody prescribed to treat relapsing-remitting multiple sclerosis (RRMS). Alemtuzumab affects the balance of the immune system by depleting circulating lymphocytes, leading to the formation of a new immune repertoire less likely to induce autoimmune attack against CNS myelin. We collected real-world data of RRMS patients treated with alemtuzumab. We assessed relapse rate, disability progression, and MRI-related disease activity over a 24 month period. Our study included 35 RRMS patients (19 female and 16 male) with a mean age of 37.3 years (SD = 10.5). The patient cohort had a mean disease duration of 10.4 years, median previous disease modifying treatments (DMTs) of 3.0, and a median expanded disability status scale (EDSS) score of 4.0 (IQR 2.5-6.0). Neurological disability remained stable during treatment and there was no statistically significant change in EDSS score. Prior to treatment, the median relapse rate was 2.0 (IQR 1.0-3.0); after treatment the median relapse rate was 0.0. This 2.0 decrease in relapse rate is statistically significant (p less then 0.0001). Moreover, the treated patients exhibited a statistically significant decrease in gadolinium (GD) enhancing lesions on MRI [both in number (p less then 0.005) and volume (p less then 0.005)]. Thirty-three percent of patients reached NEDA-3 (no evidence of disease activity) status by the end of treatment. In a real-world setting, alemtuzumab treatment significantly decreased relapse rate and GD-enhancing lesions while preventing disability progression. Tolerability of treatment was high, with patients experiencing only minor adverse events.Background Confronting a once-in-a-century pandemic with COVID-19, tremendous stress has been placed in all walks of life worldwide. Aims In order to enhance scientific information interflow in the arena of liver diseases in Asia-Pacific region during this difficult time, Asian-Pacific Association for the Study of the Liver (APASL) has taken the initiative to form the APASL COVID-19 Taskforce to formulate a clinical practice guidance in Hepatology, liver-related oncology, transplantation and conduct of clinical trials. Methods A taskforce with 22 key opinion leaders in Hepatology from 16 countries or administration regions in Asia-Pacific regions was formed and through intense interaction via webinar, this guidance was formulated. Based on scientific data and experiences, recommendations were made in the management of liver injury, liver transplantation, autoimmune diseases, chronic liver diseases, delivery of elective and emergency services and conduct of clinical trials. Conclusions This is the first consensus clinical guidance synthesized by APASL for our hepatologist and their allied medical personal.In this study, we aimed to study the role of miRNAs in intrauterine adhesion (IUA) disease. check details An IUA cell model was constructed by TGF-β1. Smad3 inhibitor (SIS3) can inhibit the Smad3 signaling pathway and affect the role of TGF-β1; thus, it was used to identify the role of Smad3 and related miRNAs in IUA. Cell number significantly increased in the TGF-β1 group after 72 h and 96 h, respectively, compared with that in the control group (P less then 0.05). However, cell proliferation was significantly decreased in the TGF-β1 + SIS3 group (P less then 0.0001). Cell apoptosis was increased in the TGF-β1 + SIS3 group compared with that in the TGF-β1 group. Western Blot (WB) analysis suggested that TGF-β1 treatment could effectively increase the expression of α-SMA, COL1, Smad3, and p-Smad3, which could be inhibited by SIS3 treatment. A total of 235 and 530 differentially expressed miRNAs in the TGF-β1 + SIS3 group were significantly up- and downregulated compared with those in the TGF-β1 group, respectively. These differentially expressed miRNAs were enriched in the MAPK and PI3K-AKT pathways. The ten most differentially expressed miRNAs were selected to verify their expressions using quantitative real-time polymerase chain reaction (qPCR). Furthermore, overexpression of rno-miR-3586-3p and rno-miR-455-5p can promote cell proliferation and exacerbate the IUA pathogenic process. However, overexpression of rno-miR-204-3p and rno-miR-3578 can inhibit cell behavior and IUA progression. The above results can provide detailed information for the understanding of IUA molecular mechanisms.