The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. Progress has been made in independently developing simple in vitro models of two primary components of the CV system, namely the heart (using induced pluripotent stem-cell derived cardiomyocytes) and the vasculature (using endothelial cells and smooth muscle cells). These two in vitro biomimics are often described as immature and simplistic, and typically lack the structural complexity of native tissues. Despite these limitations, they have proven useful for specific "fit for purpose" applications, including early safety screening. More complex in vitro models offer the tantalizing prospect of greater refinement in risk assessments. To this end, efforts to physically link cardiac and vascular components to mimic a true CV microphysiological system (CVMPS) are ongoing, with the goal of providing a more holistic and integrated CV response model. The challenges of building and implementing CVMPS in future pharmacological safety studies are many, and include a) the need for more complex (and hence mature) cell types and tissues, b) the need for more realistic vasculature (within and across co-modeled tissues), and c) the need to meaningfully couple these two components to allow for integrated CV responses. Initial success will likely come with simple, bioengineered tissue models coupled with fluidics intended to mirror a vascular component. While the development of more complex integrated CVMPS models that are capable of differentiating safe compounds and providing mechanistic evaluations of CV liabilities may be feasible, adoption by pharma will ultimately hinge on model efficiency, experimental reproducibility, and added value above current strategies.An enzyme-mediated universal fluorescent biosensor template for rapid detection of pathogens was developed based on the strategy of a three-dimensional (3D) DNA walker and catalyzed hairpin assembly (CHA) reaction. In the bacterial recognition step, a strand displacement reaction between bacteria and the double-stranded complex caused the release of the walker strand. The walker strand triggered the DNA walker to produce an enzyme fragment, and the DNA walker used gold nanoparticles (AuNPs) as the track to provide an excellent DNA ligand anchoring area. In the CHA step, the enzyme fragment induced the CHA cycle to yield fluorescence signals, which greatly enhanced the conversion ratio of trigger DNA and the sensitivity of the fluorescent biosensor. The effect of the distance and density of the DNA ligand was studied by adjusting the length of poly-adenine (PolyA), and was further explored by its reaction kinetics. By comparing the maximum reaction rate (Vmax), Michaelis constant (Km) and turnover number (Kcat), the optimized PolyA probe was assessed and identified. In this work, the optimized PolyA-DNA probe exhibited an outstanding sensitivity in Salmonella typhimurium (S. ty) detection, which is 11.9 times and 4.6 times higher than those of the SH-DNA and the MCH treated SH-DNA. Meanwhile, a detection limit of 28.1 CFU mL-1 was achieved in Escherichia coli (E. coli) detection. Furthermore, the biosensor achieved good selectivity and high repeatability with recoveries of 91%-115% for real sample detection. Considering these advantages, this template has great potential as a routine tool for pathogen detection and has wide applications in the field of global public health and food safety.The rational design of novel self-assembled nanomaterials based on peptides remains a great challenge in modern chemistry. A hierarchical approach for the construction of nanofibrils based on α,β-peptide foldamers is proposed. The incorporation of a helix-promoting trans-(1S,2S)-2-aminocyclopentanecarboxylic acid residue in the outer positions of the model coiled-coil peptide led to its increased conformational stability, which was established consistently by the results of CD, NMR and FT-IR spectroscopy. The designed oligomerization state in the solution of the studied peptides was confirmed using analytical ultracentrifugation. Moreover, the cyclopentane side chain allowed additional interactions between coiled-coil-like structures to direct the self-assembly process towards the formation of well-defined nanofibrils, as observed using AFM and TEM techniques.Designing and developing high-performance microwave absorption (MA) materials for electromagnetic protection and radar detection have received widespread attention. Recently, magnetic-dielectric MA materials have become a research hotspot due to their unique complementary functions and synergy loss mechanism. Herein, we review important research progress of excellent MA systems combining strong magnetic components and dielectric substrates. GluR agonist The functional materials involve magnetic materials, carbon components, semiconductors, polymer and so on. For a comprehensive analysis, current development and challenges are firstly introduced in the background. Modern requirements for microwave energy conversion are elaborated in the following part. To highlight the key points, more attention has been paid to the magnetic-dielectric synergy microsphere (i) core/yolk-shell structure, (ii) multi-component assembly and (iii) MOF-derived synergy composites. Meanwhile, classical and typical high-performance MA composites with a multi-loss mechanism are also mentioned in this review paper. Finally, the design principles, electromagnetic synergy, future mechanism exploration and device application are presented, which provides guidance for understanding MA materials.The influence of the free ions on the electric response of cells filled with kerosene-based ferrofluids in the low-frequency region is explored. The experimental investigations have been performed on cells limited by different types of electrodes, with the same kind of ferrofluid, by means of the impedance spectroscopy technique. The electrodes considered in our study are made of titanium, platinum, gold, brass and surgical steel. The analysis of the spectra of the real and imaginary parts of the electric impedance of the cell data has been done by means of a simplified version of the Poisson-Nernst-Planck model, in which only the carriers of a given sign are mobile. The agreement between the theoretical predictions and the experimental data is rather good on the whole frequency range. From the analysis of the data in the low-frequency range, dominated by the properties of the electrodes, we discovered that only gold electrodes behave in a manner different from the other electrodes. From the best fit of the experimental data the free-ions density is determined as well as their diffusion coefficient in kerosene.